Welcome to The Age-Related Eye Disease Study 2 (AREDS2) was a multi-center, randomized trial designed to assess the effects of oral. The Age-Related Eye Disease Study 2 (AREDS2) Research Group* . AREDS2 was designed to test whether adding lutein + zeaxanthin, DHA. Lutein + Zeaxanthin and Omega-3 Fatty Acids for Age-Related Macular Degeneration: The Age-Related Eye Disease Study 2 (AREDS2).

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Participants who were current smokers or former smokers who had stopped smoking within the year prior to enrollment were randomly assigned to one of the two arms without beta-carotene Formulations 2 or 4. Two randomized controlled clinical trials of beta carotene reported an increase in lung cancer rates and associated mortality in cigarette smokers assigned to receive beta carotene.

Another limitation would be our inability to assess the effect of the potential increased risk of lung cancer associated with beta carotene on our analyses of mortality. These percentages were similar across treatment groups for both randomizations.

Comparison with placebo in the primary analyses demonstrated no statistically significant reduction in progression to advanced AMD hazard ratio [HR], 0.

Effects of alpha-tocopherol and beta-carotene supplements on cancer incidence in the Alpha-Tocopherol Beta-Carotene Cancer Prevention Study. The recommended daily dose was therefore: Carotenoid intakes and risk of breast cancer defined by estrogen receptor and progesterone receptor status: Telephone contacts are scheduled at three- and six-months post-randomization and annually thereafter, starting at 18 months post-randomization.

The Foundation has been recommending for many years that smokers should not be taking a supplement that included beta-carotene.

Age-Related Eye Disease Study 2 (AREDS2) | National Eye Institute

Administrative, technical, or material support: Advanced age-related macular degeneration in non-study eye, less than large drusen in study eye. Participants with less than large drusen in both eyes or in study eye. Currently, cataract surgery is one of the most common surgeries conducted in the US. The key findings of the study were as follows: These analyses included all the participants randomly assigned to the variations of the AREDS supplement, including smokers.

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The sites aerds2 chosen to achieve a balance of academic and community-based practices with wide variation of geographic location in order to obtain greater generalizability of the study results.

Previous dose-ranging studies provided support for the doses used. Encyclopedia of Dietary Supplements.

It is not known whether a single specific ingredient is important or if the combination is essential for its therapeutic effect.

People with early disease or late disease in both eyes were not included in the study.

The study enrolled 4, participants aged 50 to 85 years with sufficiently clear media for quality fundus photographs and either: Funds were generously contributed to these contracts by the following NIH institutes: No apparent effect on vision of eliminating beta carotene and reducing zinc dose was observed. Several other large population studies have consistently shown that the consumption of actual fish significantly reduces the risk of AMD.

Primary Randomization A total of participants had experienced at least 1 advanced AMD event by aredd2 end of the study events in study eyes. The use of a self-administered questionnaire to assess diet four years in the past.

AREDS2 Results Released

Ancillary Studies Ancillary studies are also conducted to evaluate the role of the AREDS2 nutritional supplements on cardiovascular disease and cognitive function. Prevalence of age-related macular degeneration in the United States. Please review our privacy policy. Get free access to newly published articles.

Stduy secondary randomization allows the assessment of: Likelihood of adherence to the study regimen was evaluated during a run-in phase using study placebo and the AREDS formulation. Create a personal account to register for email alerts with links to free full-text articles.


Lutein and zeaxanthin are the only carotenoids detected in the human lens. J Am Stat Assoc.

Invest Ophthalmol Vis Sci. At each study visit, participants received a comprehensive eye examination, including best-corrected visual acuity using a standardized protocol. Effects of lutein supplementation on macular pigment optical density and visual acuity in patients with age-related macular degeneration.

The staff of the National Eye Institute and their contractors, led by Dr Chew, had complete control of the design and conduct of the study; the collection, management, analysis, and interpretation of the data; and the preparation, review, or approval ards2 the manuscript. Randomized, double-blind, placebo-controlled study of zeaxanthin and visual function in patients with atrophic age-related macular degeneration: The results presented were also analyzed with stratification by the secondary interventions.

Since beta-carotene might increase the risk of lung cancer in cigarette smokers, xreds240 and beta-carotene was included in the formulation because lutein and zeaxanthin were not commercially available at the start of the original AREDS, we developed a version of the AREDS formulation without beta-carotene.

For participants with bilateral large drusen, both eyes are eligible as study eyes because both have the potential to develop advanced AMD. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: